4/2/2023 0 Comments Jstock custom sma![]() ![]() These results demonstrate the requirement of LEC-autonomous PDGFB expression and retention for SMC recruitment to lymphatic vessels, and suggest an ECM-controlled checkpoint that prevents SMC investment of capillaries, which is a common feature in lymphedematous skin. ![]() This was explained by the demonstrated requirement of PDGFB extracellular matrix (ECM) retention for lymphatic SMC recruitment, and the low presence of PDGFB-binding ECM components around lymphatic capillaries. ![]() Unexpectedly, Pdgfb overexpression in LECs did not induce SMC recruitment to capillaries. However, vessel remodelling and identity were unaffected. LEC-specific deletion of Pdgfb prevented SMC recruitment causing dilation and failure of pulsatile contraction of collecting vessels. PDGFB is selectively expressed by lymphatic endothelial cells (LECs) of collecting vessels. Here, we demonstrate that platelet-derived growth factor B (PDGFB) regulates lymphatic SMC recruitment in multiple vascular beds. However, mechanisms controlling lymphatic SMC recruitment and its role in vessel maturation are unknown. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are thought to contribute to vessel failure, leading to lymphedema. Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. ![]()
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